ER and inflammation
Restoration of ER function in hepatocytes upon systemic inflammation; targeted diagnostic and therapeutic approaches
| Programm / Ausschreibung | FORPA, Forschungspartnerschaften NATS/Ö-Fonds, FORPA NFTE2013 | Status | abgeschlossen |
|---|---|---|---|
| Projektstart | 02.03.2015 | Projektende | 01.01.2019 |
| Zeitraum | 2015 - 2019 | Projektlaufzeit | 47 Monate |
| Keywords | |||
Projektbeschreibung
Multiple organ failure death upon systemic inflammatory response syndrome (SIRS) have still no reasonable explanation. Our preliminary data suggest that ER dysfunction, so called ER-stress is the major reason for liver failure. In the frame of this study we will clarify the mechanisms leading to ER stress and will try to recognize occurrence of these mechanism from specific IM patterns and influence these mechanisms by means of pharmacological substances in order to prevent the ER-stress and see whether or not this treatment reduces liver damage/hepatocyte dysfunction